Page 13 - HPP ANTIMICROBIAL GUIDELINE 2018
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CHEMOPROPHYLAXIS
SURGICAL
1. It is the use of antibiotics to prevent infections at the surgical site.
2. The optimal time for administration is within 60 minutes before surgical incision.
3. Giving more than 1 or 2 doses post-operatively is generally not advised.
4. The practice of continuing prophylactic antibiotic until surgical drain removal is NOT RECOMMENDED.
5. A second dose may be required in the following situations:
a. Delay in start of surgery.
b. Prolonged operations when the time is more than 2 half-life of the usual dosing interval of the antibiotic.
c. Excessive bleeding (more than 1.5L) intra-operatively.
6. Consider doubling the dose if BMI > 35.
7. Some agents, such as clindamycin, fluoroquinolones, gentamicin, metronidazole and vancomycin require administration over
1-2 hours; therefore, administration of these agents should begin within 120 minutes before surgical incision.
HPP AMG Chemoprophylaxis 1