Page 41 - HPP ANTIMICROBIAL GUIDELINE 2018
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BONE & JOINT INFECTIONS
Suggested Treatment
Infection/ Condition Comments
Preferred Alternative
Acute osteomyelitis Cloxacillin 2gm IV q6h Cefazolin 2gm IV 6-8hrly Duration:
Initial IV therapy for 2-4 weeks
followed by oral therapy
Total duration of treatment minimum
6 weeks
Modify according to clinical response
A shorter duration of antibiotics can
be considered if the osteomyelitic
bone is fully resected
( i.e amputation with a clear margin)
Chronic osteomyelitis Empirical treatment before taking Duration :
adequate cultures is not 6 weeks but usually > 3 months.
recommended.
A shorter duration of antibiotics can
Choice of antibiotic depends on be considered if the osteomyelitis is
C&S result from tissue/bone as fully resected ( i.e amputation with a
swab culture NOT reliable. clear margin)
Treat until inflammatory parameters
are normal.
Thorough surgical debridement
required.
(Removal of dead bone/ orthopaedic
hardware)
HPP AMG Bone & Joints Infections 15
