Page 100 - HPP ANTIMICROBIAL GUIDELINE 2018
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Suggested Treatment
Infection/ Condition Comments
Preferred Alternative
Extraocular CMV diseases Ganciclovir 5mg/kg IV q12h for Maintenance therapy with Maintenance therapy is generally
(Oesophagitis, colitis, interstitial 14-21 days or until signs and valganciclovir* 900mg PO q24h not necessary; HAART offers best
pneumonitis, neurological) symptoms have been resolved hope for prevention of relapses
Salmonellosis (Bacteraemia) Ceftriaxone 2gm IV q24h Trimethoprim(TMP)/sulfamethoxazole Duration:
Salmonella non-typhi (80/400mg) TMP 10mg/kg/q24h CD4≥200: 7-14 days.
IV/PO in 2 divided doses CD4 <200 and with bacteraemia:
4-6 weeks.
Longer course with debridement and
drainage needed for persistent
bacteraemia or metastatic disease
Herpes Simplex Virus (HSV) Infections
Genital or orolabial Duration:
Mild Acyclovir 400mg PO q8h Genital : 5-14 days
Orolabial: 5-10 days
Moderate-to-severe Acyclovir 5mg/kg IV q8h
mucocutaneous infections Suppressive therapy indicated if
severe/frequent recurrences
Suppressive therapy Acyclovir 400mg PO q12h Duration: Continue until immunity is
restored
Varicella-Zoster Virus Diseases
Duration:
Uncomplicated/Acute Localized Acyclovir 800mg PO 5x/day Shingles : 7-10 days
Dermatomal Chickenpox : 7 days
Severe infection Acyclovir 10-15mg/kg IV q8h, then Duration:
(CNS, ocular, disseminated) switch to oral regime as above when Shingles : 10-14 days
improved Chickenpox : 7-10 days
HPP AMG Human Immunodeficiency Virus 45
