Page 167 - HPP ANTIMICROBIAL GUIDELINE 2018

Suggested Treatment
Infection/ Condition Comments
Preferred Alternative

Candidiasis
Mild cutaneous candidiasis Topical imidazole q12h till clear e.g. Fluconazole 100mg PO q24h for 1 week Treatment of sexual partner is
miconazole 2% cream, clotrimazole (in severe and immunocompromised advisable in case of recurrent
1% cream, tioconazole 1% cream patients) infection.

Extensive cutaneous candidiasis Itraconazole 200mg PO q24h for
1 week

Subcutaneous Fungal Infections
1 (Sporotrichosis)
Localized to skin only Itraconazole 200mg PO q24h Fluconazole 400-800mg q24h In some immunocompromised
for 3-6 months for at least 2-4 weeks condition such as AIDS,
after recovery. OR longer treatment may be
(max 200mg q12h, if no response) Potassium iodide necessary. Refer to
(saturated solution 50mg/drop) 5 drops Opportunistic Infections In
OR q8h may increase to 40-50 drops q8h HIV Patients
Terbinafine 250mg q24h/q12h
(max 500mg BD, if no response) Avoid azole in pregnancy

Severe life threatening Amphotericin B, (lipid formulation)
3–5mg/kg q24h,
or amphotericin B (deoxycholate),
0.7–1mg/kg q24h,

Step down therapy:
Itraconazole 6–10mg/kg
(maximum of 400mg)PO q24h

HPP AMG Skin & Soft Tissue Infections 78