Page 186 - HPP ANTIMICROBIAL GUIDELINE 2018

Suggested Treatment
Infection/ Condition Comments
Preferred Alternative

Malaria Chemoprophylaxis Doxycycline 100mg PO q24h Mefloquine 250mg PO weekly Pregnancy: Only mefloquine can be
Start: 1-2 days before departure, Start: 2 weeks before departure, used
continue daily until 4 weeks after continue weekly until 4 weeks after
travel. travel Refer to the drug resistance pattern
Max duration: 2 years Max duration: 1 year and recommended prophylaxis in the
travel destination
OR
Atovaquone/proguanil (Malarone®)* Mefloquine can cause
100/250mg q24h neuropsychiatric symptoms.
Start: 1-2 days before departure, Mefloquine and malarone are not in
continue daily until 7 days after travel KKM formulary

References:
1. Parry CM et al. Typhoid fever. N Engl J Med 2002; 347:1770.
2. Saha D et al. Single-dose azithromycin for the treatment of cholera in adults. N Engl J Med 2006; 354:2452.
3. CPG Brucellosis, Ministry of Health 2012.
4. Melioidosis: The 2014 Revised RDH Guideline. Royal Darwin Hospital and Menzies School of Health Research, Darwin. The Northern Territory
Disease Control Bulletin Vol 21 No. 2 June 2014.
5. CPG Leptosiprosis, Ministry of Health 2011.

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