Page 306 - HPP ANTIMICROBIAL GUIDELINE 2018

EXAMPLES OF
CONVERSION IV DOSAGE ORAL EQUIVALENT
REGIMENS

Amoxicillin/ 1.2g IV every 8 hours 625mg PO every 8 hours
clavulanate
OR
Ampicillin/ 1.5g IV every 8 hours
sulbactam 375 – 750mg every 12 hours

Azithromycin 250mg IV daily 250mg PO daily

500mg IV daily 500mg PO daily

Benzylpenicillin 1.2g IV every 6 hours Phenoxymethylpenicillin (Pen V) 500mg PO every 6 hours

Cefazolin 1g IV every 8 hours Cephalexin 500mg PO every 6 hours/ Cloxacillin 500mg
every 6 hours

Ceftriaxone Choice of oral antibiotic depends on infection site/microbiology

Cefuroxime 750mg every 8 hours Cefuroxime axetil 500mg PO every 12 hours
OR
Amoxicillin/clavulanate 625mg PO every 8 hours
OR
Ampicillin/sulbactam 375 – 750mg every 12 hours

1.5g every 8 hours Amoxicillin/clavulanate 625mg PO every 8 hours
OR
Ampicillin/sulbactam 375 – 750mg every 12 hours

Clindamycin 600mg IV every 8 300mg PO every 6 hours
hours OR
600mg PO every 8 hours

Cloxacillin 1g IV every 6 hours 500mg every 6 hours

Fluconazole 100mg IV daily 100mg PO daily

200mg IV daily 200mg PO daily

400mg IV daily 400mg PO daily

Levofloxacin 500mg IV daily 500mg PO daily

Linezolid 600mg IV every 12 600mg PO every 12 hours
hours
Metronidazole 500mg IV every 8 400mg PO every 8 hours
hours
Moxifloxacin 400mg IV daily 400mg PO daily

Piperacillin/ Choice of oral antibiotic depends on infection site/microbiology
tazobactam

Trimethoprim/ 5 – 15mg of 5 – 15mg of TMP/kg/day in 2 – 4 divided doses
sulfamethoxazole TMP/kg/day in
2 – 4 divided doses

HPP AMG Guide To Antimicrobial Intravenous To Oral Conversion 148