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INCLUSION CRITERIA

• Clinical improvement is observed
• Able to swallow and tolerate oral fluids
• Afebrile ( Temperature >36°C or < 38°C)
• Heart rate < 90 bpm for the last 12 hours
• Normalization of white cell count and inflammatory markers (eg. CRP, ESR)
• Non neutropenic sepsis

EXCLUSION CRITERIA

• Deep seated infection that may require an initial 2 weeks of IV therapy for example, liver abscesses, osteomyelitis,
septic arthritis, empyema, cavitating pneumonia, melioidosis
• High risk infections requiring prolonged therapy, for example, Staphylococcus bacteraemia, severe necrotising soft
tissue infections, severe infections during chemotherapy related neutropenia, infected implants/prosthesis,
meningitis/encephalitis, intracranial abscesses, mediastinitis, endocarditis, inadequate drained abscesses/empyema
• Persistent nausea and vomiting, diarrhoea
• Patient with the following GI conditions:
• Ileus or suspected ileus with no active bowel sound
• Patient is known to have malabsorption syndrome
• Proximal resection of small intestines
• High nasogastric tube output or requiring continuous GI suction (>500mL/day)
• Active GI bleed
• Neutropenic patient

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