Page 92 - HPP ANTIMICROBIAL GUIDELINE 2018
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Human Immunodeficiency Virus (HIV)
Suggested Treatment
Infection/ Condition Comments
Preferred Alternative
Pneumocystis pneumonia (PJP) Trimethoprim(TMP)/sulfamethoxazole Pentamidine 4mg/kg/24h IV Patients with severe disease should
(80/400mg) TMP 15-20mg/kg/24h (in 1 pint D5% or N/S run over receive steroids as soon as possible
IV/PO (excellent bioavailability) in 3 1-2 hours) for 21 days (within 72 hours of starting PJP
divided doses for 21 days treatment):
OR
Prednisolone 40mg PO q12h for 5
Clindamycin 600mg IV/PO q8h days,
PLUS then 40mg PO q24h for 5 days,
Primaquine 30mg base PO q24h for then 20mg PO q24h for 11 days
21 days
Patients given primaquine should
Prophylaxis Trimethoprim/Sulfamethoxazole Dapsone 100mg PO q24h be tested for G6PD deficiency
(primary and secondary) (80/400mg) 2 tabs PO q24h
Mucocutaneous Candidiasis
Oropharyngeal Fluconazole 100-200mg PO q24h Itraconazole 200mg PO q24h Duration: 7-14 days
(oral thrush)
OR
Nystatin suspension 500,000 units
PO q6h
Oesophageal Fluconazole 200-400mg PO/IV q24h Itraconazole 200mg PO q24h Duration : 14-21 days
Vulvovaginal Fluconazole 200mg PO stat Itraconazole 200mg PO q24h for 3
days
HPP AMG Human Immunodeficiency Virus 41
