Page 238 - HPP ANTIMICROBIAL GUIDELINE 2018
P. 238
Infection/Condition Suggested Treatment Comments
Preferred Alternative
Early onset sepsis (<48 hrs) Suspect in maternal chorioamnionitis, sepsis, PROM (>18 hours)
Sepsis / pneumonia /
meningitis) Do full septic workup, CXR
GBS, GNB
In babies given antibiotics because of risk factors for infection or clinical indicators of possible infection, review need for
continued antibiotics at 36 hours with culture results
No evidence from randomised trials to suggest that any antibiotic regimen may be better than any other in the treatment
of presumed early neonatal sepsis
Tailor according to culture results
Drug Dosages – Refer Frank Shann or Neofax
Penicillin G IV Duration:
Sepsis: 7-10 days
OR
Ampicillin IV Gram positive meningitis: 2 weeks
PLUS Gram negative meningitis: 3 weeks
Gentamycin IV
For meningitis Ampicillin IV
Pathogen unknown
PLUS
Cefotaxime IV
HPP AMG Neonatal Infections 114
