Page 235 - HPP ANTIMICROBIAL GUIDELINE 2018

Infection/Condition Suggested Treatment Comments
Preferred Alternative

Tetanus neonatorum • Debridement
• Human tetanus IG IM
Optimum dose for IM human TIG yet to be established.
Traditional recommendations: single dose of 3000-6000U.
Limited data suggests doses as low as 500U as effective.

Penicillin - GABA antagonist and associated with seizures. Metronidazole recommended as choice.

Check maternal immunization

Metronidazole IV/PO for 10 days Penicillin G IV
(100 000U/kg q12h for
Neonates (Neofax dosing): 1st week of life and
st
• Loading dose: 15mg/ kg/dose IV/PO x 1 q6h after 1 week) for
• Maintenance dose: 7.5mg/ kg/dose IV/PO 10 days

Metronidazole Dosing Interval Chart
Post-menstrual Post-natal Dosing
age (weeks) age (days) interval
(hours)
≤ 29 weeks 0-28 days q48h
>28 days q24h
30 to 36 weeks 0-14 days q24h
>14 days q12h
37 to 44 weeks 0-7 days q24h
>7 days q12h
≥ 45 weeks AL q8h

HPP AMG Neonatal Infections 112