Page 236 - HPP ANTIMICROBIAL GUIDELINE 2018

Infection/Condition Suggested Treatment Comments
Preferred Alternative
•
Gonococcal • Evaluate for signs of disseminated
infection (e.g., sepsis, arthritis, and
Ophthalmitis Immediate and frequent saline eye irrigation meningitis)
•
• Screen mother and baby for
Non-disseminated disease Ceftriaxone 50mg/kg IV once (max 125mg) chlamydial infection
•
• Screen for other STDs
st
Disseminated disease Ceftriaxone IV (50mg/kg daily 1 week of life, 12H • Investigate and treat parents
>1week of life) for 7 days
Duration 10-14 days if meningitis documented

Neonates with Cefotaxime 25 mg/kg IV/IM q12h for 7 days,
hyperbilirubinemia with a duration of 10–14 days, if meningitis is
documented

Chlamydia trachomatis Initial treatment for chlamydial conjunctivitis should be based upon a positive diagnostic test
conjunctivitis Diagnosis by tissue culture, antigen detection (IFA, EIA) or NAAT
Eye swab from conjunctiva of everted eyelid with Dacron tipped swab or swab from test kit
Test also for gonococcus.
Treat mother & sexual partner

• Efficacy of treatment 80%, follow-up necessary. Second course of treatment may be required.
•

Erythromycin base or ethylsuccinate 50mg/kg/day PO Azithromycin 20
q6h for 14 days mg/kg/day PO, 1 dose
daily for 3 days
(Topical therapy not necessary if systemic treatment
given)

HPP AMG Neonatal Infections 113