Page 267 - HPP ANTIMICROBIAL GUIDELINE 2018
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Infection/Condition Suggested Treatment Comments
Preferred Alternative
Leptospirosis
L. icterohaemorrhagiae Benzylpenicillin 100,000 units/kg IV q6h Ceftriaxone 80-100mg/kg IV q24h
Moderate to severe disease (max 6-12 millions unit/day) for 7 days (max 2gm/day) for 7 days
OR
Cefotaxime 150-200mg/kg/24h IV q6h-q8h
(max 12gm/day) for 7 days
Mild disease Amoxicillin 25-50mg/kg PO q6h-q8h For children > 8 yr:
(max 500mg/dose) for 7 days Doxycycline 2mg/kg PO q12h
(max 200mg/day) for 7 days
Tetanus Refer to Neonatal Infections Section
Melioidosis
Burkholderia pseudomallei
Intensive/Induction therapy: Ceftazidime 200mg/kg/24h IV q6h for 10-14 days For children > 8 yr: Imipenem/cilastatin Parenteral treatment
75-100mg/kg/24h IV q6-8h should be used for at
least 10-14 days or
OR until clear improvement
Meropenem 75mg/kg/24h IV q8h is noted
Folic Acid 5mg PO
Maintenance therapy: Amoxicillin (60mg/kg/24h)/ clavulanate PO q8h q24h to be given for
patient on trimethoprim/
OR sulfamethoxazole
Trimethoprim(TMP)/sulfamethoxazole TMP
8mg/kg PO q12h Duration: 12-20 weeks
HPP AMG Tropical Infections 128
