Page 285 - HPP ANTIMICROBIAL GUIDELINE 2018

ADJUSTMENT FOR RENAL FAILURE
DOSE FOR
ANTIBACTERIAL NORMAL RENAL Estimated creatinine clearance (CrCl), SUPPLEMENT FOR COMMENTS
ml/min
DIALYSIS
FUNCTION
> 50 10-50 < 10

Carbapenem

Meropenem 1-2gm q8h 100% 26-50ml/min: 50% q24h Dose AD
100% q12h

10-25ml/min:
50% q12h

Ertapenem 1gm q24h 100% <30ml/min: 50% q24h PD : Dose for CrCl <10

ADJUSTMENT FOR RENAL FAILURE
DOSE FOR NORMAL Estimated creatinine clearance (CrCl), SUPPLEMENT FOR
ANTIBACTERIAL COMMENTS
RENAL FUNCTION ml/min DIALYSIS
41-70 21-40 6-20

Imipenem/cilastatin 1000mg q6h 750mg q8h 500mg q6h 500mg q12h Dose AD

1000mg q8h 500mg q6h 500mg q8h 500mg q12h

500mg q8h 500mg q8h 250mg q6h 250mg q12h

AD = after dialysis. “Dose AD” refers only to timing of dose with NO extra drug
D = dosage reduction, I = interval extension, SGC=Soft gel capsule, HD – Haemodialysis, PD – Peritoneal dialysis

HPP AMG Antibiotic Dosage In Patients With Impaired Renal Function 137