Page 287 - HPP ANTIMICROBIAL GUIDELINE 2018
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ADJUSTMENT FOR RENAL FAILURE
DOSE FOR NORMAL SUPPLEMENT FOR
ANTIMICROBIAL Estimated creatinine clearance (CrCl), ml/min COMMENTS
RENAL FUNCTION DIALYSIS
> 50 10-50 < 10
Cephalosporin
Cefazolin 250mg- 2000mg q6h 100% q8h 100% q12h 50% 15-20mg/kg AD
q24-48h
Cefotaxime 1-2gm q6-12h q6h q6-12h q24h or ½ dose 0.5-2gm AD
Cefoperazone/ sulbactam 2gm q12h 2gm q12h 2gm q12h 1gm q12h Dose AD
Ceftazidime 1-2gm q8h 100% q12-24h q24-48h Dose AD
Cefuroxime sodium 0.75-1.5gm q8h q8h q8-12h q24h Dose AD
Cefuroxime axetil 250mg-500mg q12h 100% 100% 100% Dose AD
ADJUSTMENT FOR RENAL FAILURE
DOSE FOR NORMAL SUPPLEMENT FOR
ANTIBACTERIAL Estimated creatinine clearance (CrCl), ml/min COMMENTS
RENAL FUNCTION DIALYSIS
30-60 11-29 <11
Cefepime 2g q8h 2g q8h 2g q12-24h 1g q24h Dose for CrCl<10
2g q12h 2g q12h 1-2g q24h 500mg q24h
1g q12h 1g q12h 500mg-1g q24h 250mg q24h
HPP AMG Antibiotic Dosage In Patients With Impaired Renal Function 138
