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Appendix 2: Penicillin Allergy
Severe allergy Non- severe allergy
Anaphylaxis Maculopapular/ morbilliform rash
Angioedema Serum sickness
Urticarial rash • Fever
Wheezing/ stridor • Rash
Stevens-Johnson syndrome • Arthralgia
Drug Rash with Eosinophilia and systemic Symptoms • Glomerulonephritis
(DRESS)
Toxic Epidermal Necrolysis (TEN)
Considered Safe Caution Contraindicated
Avoid in severe allergy Avoid in all penicillin
allergy
Amikacin Cefalexin Amoxicillin
Azithromycin Cefixime Ampicillin
Chloramphenicol Cefotaxime Amoxicillin/clavulanate
Ciprofloxacin Ceftazidime Ampicillin/sulbactam
Clarithromycin Ceftriaxone Cloxacillin
Clindamycin Cefuroxime Flucloxacillin
Colistin Ertapenem Penicillin G
Co-trimoxazole Imipenem/cilastatin Penicillin V
Doxycycline Meropenem Piperacillin/tazobactam
Erythromycin Aztreonam Ticarcillin/ tazobactam
Fosfomycin
Gentamycin
Levofloxacin
Linezolid
Metronidazole
Nitrofurantoin
Norfloxacin
Ofloxacin
Rifampicin
Teicoplanin
Tetracycline
Tigecycline
Trimethoprim
Vancomycin
HPP AMG Penicillin Allergy 144
