Page 57 - HPP ANTIMICROBIAL GUIDELINE 2018
P. 57
Suggested Treatment
Infection/Condition Comments
Preferred Alternative
Native valves Vancomycin 25-30mg/kg loading
Methicillin-resistant dose then 15-20mg/kg IV q12h for
Staphylococcus aureus 6 weeks, not to exceed 2g/dose
Prosthetic valves Vancomycin 25-30mg/kg loading
Methicillin-resistant dose then 15-20mg/kg IV q12h for
Staphylococcus aureus ≥ 6 weeks, not to exceed 2g/dose
PLUS
Rifampicin 450mg PO q12h for
≥ 6 weeks
PLUS
Gentamicin 1mg/kg IV q8h for
2 weeks
HACEK Microorganisms Ceftriaxone 2gm IV q24h for Ampicillin/sulbactam 3gm IV q6h for
4 weeks (native valve) 4 weeks (native valve) or 6 weeks
or (prosthetic valve)
6 weeks (prosthetic valve)
OR
Ciprofloxacin 400mg IV q12h or
500mg PO q12h for 4 weeks (native
valve) or 6 weeks (prosthetic valve)
Brucella spp Doxycycline 100mg PO q12h Doxycycline and rifampicin should
PLUS be continued for 3-6 months
Rifampicin 300-600mg q24h
Streptomycin or gentamicin for
PLUS 2-3 weeks
Streptomycin 1gm IM q24h
Or
Gentamicin 5mg/kg IV q24h
HPP AMG Cardiovascular Infections 23
