Page 141 - HPP ANTIMICROBIAL GUIDELINE 2018
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Suggested Treatment
Infection/ Condition Comments
Preferred Alternative
Rhinology
Acute Bacterial Rhinosinusitis
(ABRS)
Mild infection Amoxicillin 500mg PO q8h Cefuroxime 250mg-500mg PO q12h Duration: 5-10 days
Pregnant patients with
Severe infection requiring Ampicillin/sulbactam 3gm IV q6h penicillin allergy would need
hospitalization: to be treated with
OR azithromycin 500mg PO
Amoxicillin/clavulanate 1.2gm IV q8h q24hr
Otology
Acute otitis media
For severe disease or Amoxicillin 500mg PO q8h Penicillin Allergy: Antibiotics should not be
when risk of complications Clarithromycin 500mg PO q12h routinely prescribed for
If not responding 48-72hrs; uncomplicated AOM.
Amoxicillin/clavulanate 625mg PO q8h OR
for 5 days Azithromycin 500mg PO on day 1,
followed by 250mg PO OD on day 2
OR through day 5
Ampicillin/sulbactam 375mg PO q12h
Malignant Otitis Externa/ Ceftazidime 2gm IV q8h
Necrotizing Otitis Externa followed by
Ciprofloxacin 750mg PO q12h for
6 weeks
HPP AMG Otorhinolaryngology Infections 65
