Page 157 - HPP ANTIMICROBIAL GUIDELINE 2018
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SKIN & SOFT TISSUE INFECTIONS
Suggested Treatment
Infection/ Condition Comments
Preferred Alternative
Impetigo Cloxacillin 500mg PO q6h for Cephalexin 500mg PO q6h for 5-7 days
5-7 days
OR
Penicillin Allergy Amoxicillin/clavulanate 625mg PO q8h for
Erythromycin ethylsuccinate 800mg 7-10 days
PO q12h for 5-7 days
Ecthyma gangrenosum Piperacillin/tazobactam 4.5gm IV q6h Cefepime 2gm IV q8h
Boils/Carbuncles Cloxacillin 500mg PO q6h Cefuroxime 500mg PO q12h Surgical drainage is important
in the management
OR
Amoxicillin/clavulanate 625mg PO q8h Duration: 7-10 days
Erysipelas
out-patient Penicillin PO 500mg q6h Amoxicillin 500mg PO q8h Treatment duration:
5-14 days, depending on
clinical response
In-patient Ampicillin/sulbactam 1.5–3gm IV q6h Cefazolin 1gm IV q8h
OR
Amoxicillin/clavulanate 1.2gm IV q8h
HPP AMG Skin & Soft Tissue Infections 73
