Page 107 - HPP ANTIMICROBIAL GUIDELINE 2018
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Suggested Treatment
Infection/ Condition Comments
Preferred Alternative
Chorioamnionitis Cefuroxime 1.5gm IV q8h Ampicillin/sulbactam 3gm IV q6h Antibiotic regimen is continued
postpartum until patient is
PLUS afebrile and asymptomatic for
Metronidazole 500mg IV q8h AT LEAST 48 HOURS
Pelvic Inflammatory Disease Azithromycin 1gm PO in a single Ampicillin/sulbactam 3gm IV q6h Duration of treatment is 14 days
Mild-moderate dose
PLUS PLUS
Metronidazole 400mg PO q12h Doxycycline100mg PO q12h
PLUS
Doxycycline 100 mg PO q12h for
14 days
Inpatient Regimen (Moderate-severe) Cefuroxime 1.5gm IV q8h
PLUS
Doxycycline 100mg PO q12h
PLUS
Metronidazole 500mg IV/PO q8h
Tubo-ovarian abscess Cefuroxime 1.5gm IV q8h
PLUS
Doxycycline 100mg PO q12h
PLUS
Metronidazole 500mg IV/PO q8h
Endometritis Cefuroxime 1.5gm IV q8h Amoxicillin/clavulanic 1.2g IV q8h Surgical intervention for source
Non pregnancy/ PLUS control may be required.
Post-partum endometritis Doxycycline 100mg PO q12h OR
PLUS Ampicillin/sulbactam 3gm IV q6h Duration of treatment is 10-14
Metronidazole 500mg IV/PO q8h days
HPP AMG Obstetrics & Gynaecological Infections 48
