Page 110 - HPP ANTIMICROBIAL GUIDELINE 2018

Suggested Treatment
Infection/ Condition Comments
Preferred Alternative

Postpartum mastitis

Outpatient: Cloxacillin 500mg PO q6h for Cephalexin 500mg PO q6h for 5-7days Duration of therapy for 5-7 days
5-7days
If poor response consider
Inpatient: Cloxacillin 2g IV q6h Cefazolin 1gm IV q8h extending to 10-14days

Reference:

1. Mackeen A, Packard RE, Ota E, Speer L. Antibiotic Regimens for postpartum endometritis. Cochrane Database Syst Rev 2:2015
2. Prevention of early-onset Group B Streptococcal Disease in newborns. Committee Opinion No. 485.American College of Obstetricians and Gynecologists.
ObstetGynecol 2011;117:1019-27
3. Hughes RG, Brocklehurst P, Steer PJ, Heath P, Stenson BM on behalf of the Royal College of Obstetricians and Gynaecologists. Prevention of early-onset
neonatal group B streptococcal disease. Green-top Guideline No. 36. BJOG 2017;124:e280–e305.
4. NICE Guideline.Pretermlabor and birth.https://www.nice.org.uk/guidance/ng25/resources/preterm-labour-and-birth
5. UK National Guideline for Management of Pelvic Inflammatory Disease 2011. Clinical Effectiveness Group British Association for Sexual Health and HIV.
2011
6. World Health Organization; Mastitis: causes and management; Geneva, Switzerland; accessed21/3/2018
7. Workowski KA, Bolan GA, Centers for Disease Control and Prevention: Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep
64:1, 2015

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