Page 125 - HPP ANTIMICROBIAL GUIDELINE 2018

Suggested Treatment
Infection/ Condition Comments
Preferred Alternative

Endogenous Endophthalmitis Ciprofloxacin 750mg PO q12h for Moxifloxacin 400mg PO q24h for Treatment is based on primary
Systemic treatment 10days 10 days (caution in children) infection ( bacterial/fungal etc) and
culture and sensitivity results
For culture negative cases add: OR
Clarithromycin 250-500mg PO q12h Vancomycin and ceftazidime IV All cases require systemic therapy
for 7-14 days
Intravitreal injection is indicated in
cases with vitreous involvement and
sight threatening choroidal lesions
Topical treatment-options: *Ceftazidime 5% eye drop, Vancomycin 1-2mg in 0.1ml
*Vancomycin 5% eye drop, Topical therapy may supplement
Gentamycin 0.3% eye drop PLUS therapy. Not to use systemic steroids
Moxifloxacin 0.5% eye drop Amikacin 0.4mg in 0.1ml in these cases
Levofloxacin 0.5% eye drop
(monotherapy or combination) *Prepared ready to use
extemporaneously by injectable forms

Intravitreal antibiotic injections: Vancomycin 1-2mg in 0.1ml

PLUS
Ceftazidime 2mg in 0.1ml

Ocular Melioidosis For ocular manifestations of Melioidosis, refer to treatment of Melioidosis infection

Ocular Bartonellosis For ocular manifestations of Bartonella, refer to treatment of Bartonella infection

Ocular Leptospirosis For ocular manifestations of Leptospira, refer to treatment of Leptospira infection

HPP AMG Ocular Infections 57