Page 205 - HPP ANTIMICROBIAL GUIDELINE 2018

Pertussis

Antimicrobial prophylaxis for close contacts of the index case and for exposed individuals at high risk for severe or complicated pertussis
Close contact definition:

• Face-to-face exposure within three feet of a symptomatic patient

• Direct contact with respiratory, oral, or nasal secretions from a symptomatic patient

• Sharing the same confined space in close proximity with a symptomatic patient for ≥1 hour

At risk:
• Infants younger than one year, especially <4 months of age

• Persons with immunodeficiency

• Persons with underlying medical conditions (chronic lung disease, respiratory insufficiency, cystic fibrosis)

• People in close contact with high risk patients

Complete immunization for close contact  7 years of age
Routine vaccination of children, adolescents, and adults (including pregnant women) is the most important preventive strategy

Suggested Treatment
Infection/Condition Comments
Preferred Alternative

Pertussis <1 month : >1 month:
Azithromycin 10mg/kg q24h for 5 days Clarithromycin 15 mg /kg /day PO q12h
for 7 days
>1 month :
Erythromycin ethylsuccinate 40- Azithromycin 10mg/kg q24h for 5 days
50mg/kg/day q6-12h for 14 days

HPP AMG Chemoprophylaxis 97