Page 72 - HPP ANTIMICROBIAL GUIDELINE 2018

Suggested Treatment
Infection/ Condition Comments
Preferred Alternative

Infectious Diarrhoea
- Most infectious diarrhoea is self-limiting and only requires supportive management.
-Treatment with antibiotics is not recommended for mild-moderate disease.
-Treatment recommended for:
• severe illness
• age <6/12 or >50 years old
• gross blood in stool
• high grade fever >38°C
• worsening or relapse/persistent of symptoms >1 week
• immunocompromised host
• excessive bowel movement >8 times a day

Shiga toxin producing E.coli, Ciprofloxacin 500mg PO q12h for 3-5 days Trimethoprim/Sulfamethoxazole
Klebsiella oxytoca, (80/400mg) PO 2 tabs q12h for
Aeromonas/Plesiomonas, 3-5 days
Yersinia species

Campylobacter jejuni Azithromycin 500mg PO q24h for 3 days Ciprofloxacin 500mg PO q12h

Salmonella, non-typhi Do not routinely require treatment, Trimethoprim/Sulfamethoxazole Duration of treatment 5-7
unless immunocompromised (80/400mg) PO 2 tabs q12h days, 14 days if relapse
(if susceptible)

Ciprofloxacin 400mg IV q8 h OR
Ceftriaxone IV 1g q24h

Vibrio cholerae Doxycycline 300 mg PO single dose **Azithromycin 500mg PO q24h for Primary therapy is
3 days rehydration. Select antibiotics
based on local susceptibility
**Pregnant use Azithromycin

HPP AMG Gastrointestinal Infections 31