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Suggested Treatment
Infection/ Condition Comments
Preferred Alternative
Shigella sp. Ciprofloxacin 750mg PO q12hr Ceftriaxone 50-75mg/kg IV daily for In immunocompromised
for 3 days 5 days. (for severe disease) patients duration of antibiotic
10 days
OR
Azithromycin 500mg PO q24h Avoid prescribing
for 3 days fluoroquinolones if the
ciprofloxacin MIC is
0.12ug/mL or higher
Giardia Metronidazole 400mg PO q8h for 7 days
Entamoeba histolytica Metronidazole 800 mg PO q8h for
5–10 days
Clostridium difficile
Mild to moderate Vancomycin 125mg PO q6h for Repeating test on stool within
10- 14 days 7 days is not recommended
severe, complicated Vancomycin 250mg- 500mg PO q6h Oral vancomycin
PLUS preparation guide:
Metronidazole 500mg IV q8h for 10-14 days -Use the vial with 500mg
vancomycin.
-Dilute it with 10ml water for
First recurrence Same as for initial episode injection.
-The solution becomes
Second recurrence Vancomycin 125mg PO q6h for 7-14 days 50mg /ml
then -For 125mg PO draw out
125mg PO q12h for 7 days then 2.5ml.
125mg PO q24 for 7 days then -Add 30ml of drinking water to
125mg PO every other day for 7 days then the 2.5ml. (optional)
125mg PO every 3 days for 14 days -Administer orally or through
NG tube.
HPP AMG Gastrointestinal Infections 32
